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Dre Greenlaw’s Knee AND Trent Williams’ Shoulder Are a Major Headache for the 49ers

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San Francisco 49ers logo on gradient background — Created by the Sports On Tap desk | Source : Sports On Tap (team logos property of their respective owners)

The San Francisco 49ers got a dose of bad news on Thursday when both linebacker Dre Greenlaw and left tackle Trent Williams were listed as limited participants in practice. After both players rested on Wednesday, seeing them back on the field, but still hampered, isn’t exactly what you want before a big road game. Greenlaw is dealing with a knee injury, while Williams has a shoulder injury, raising some serious questions about their availability.

Key Players Limping Into the Weekend

This isn’t just a couple of backups we’re talking about here. Greenlaw and Williams are absolutely critical to how the 49ers operate. Greenlaw’s presence in the middle of that defense is huge, and a knee injury on top of a shoulder issue for Williams, the anchor of their offensive line, could spell trouble. Seeing them both limited on Thursday after a rest day on Wednesday tells you these aren’t minor bumps.

The Rest of the Report: More Missing Pieces

It wasn’t just Greenlaw and Williams feeling the heat. Wide receiver Mike Evans (Achilles), cornerback Renardo Green (back), and cornerback Deommodore Lenoir (foot) all missed practice for the second straight day. That’s a significant chunk of talent on the sidelines. Plus, safety Siran Neal (knee, foot), wide receiver Deebo Samuel (hamstring), cornerback Upton Stout (shoulder, neck), and defensive tackle C.J. West (knee) remained in the limited category, just like Greenlaw and Williams. It’s a long list of guys not at 100%.

The 49ers have a road game against the Cowboys coming up. We’re going to find out exactly who’s in and who’s out when they drop their official injury designations on Friday. This injury report could swing things big time for that matchup.

This article was created with AI assistance and published under Seattle On Tap’s editorial standards. See our Editorial Policy.

Originally reported by Pro Football Talk.

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