With no NFL games on Sunday, September 6, college football is taking center stage, and the Week 1 slate is dishing up two absolute must-watch primetime battles: Wisconsin vs. Notre Dame and Louisville vs. Ole Miss. These are huge early season matchups, and if you’re eyeing the action, a FanDuel promo code offers $350 in bonus bets for wagering $5+ for seven days on Sunday’s games. The SportsLine Projection Model, which is on a crazy 32-19 run on top-rated CFB money line picks since the 2024 season and got an upgrade for 2026, has dropped its predictions, and they are wild.
The Irish Are Coming For You, Wisconsin
First up, we’ve got a battle between two prominent Midwest programs at Lambeau Field: Notre Dame vs. Wisconsin. The Irish are coming off a College Football Playoff snub in 2025, and believe me, they are among the favorites to win the national title in 2026. This team has something to prove! On the other side, Wisconsin definitely tried to step up, bolstering its NIL spending over the offseason to build a competitive roster in the rugged Big Ten. But the SportsLine model isn’t buying that it will be close. It projects Notre Dame to cover that massive 20.5-point spread in a solid 54% of simulations. That’s a ton of confidence in the Irish to absolutely roll right out of the gate.
Ole Miss’s CFP Dreams Are Riding On This One
Then we shift gears to Ole Miss vs. Louisville, a game with serious implications. Ole Miss had its best season in recent memory in 2025, reaching the CFP semifinal. And guess what? Their quarterback Trinidad Chambliss is back, along with star rusher Kewan Lacy. Pete Golding, who was part of that CFP run, is taking over as the permanent Rebels coach after Lane Kiffin bolted for LSU. Louisville won’t be a pushover, though. The Cardinals have steadily ascended under Jeff Brohm, winning nine games every single season under their Louisville native coach. They could be a sneaky contender in an open ACC. Still, the SportsLine model is backing the Rebels hard in this opener, projecting Ole Miss to cover the 6.5-point spread in 57% of simulations. They clearly think that Ole Miss offense is for real.
So, get ready for some intense college football action this Sunday, September 6. These games aren’t just for bragging rights; they could set the tone for national title and playoff aspirations. It’ll be fascinating to see if the SportsLine model’s confidence in Notre Dame’s huge cover and Ole Miss’s continued success plays out on the field.
This article was created with AI assistance and published under Seattle On Tap’s editorial standards. See our Editorial Policy.
Originally reported by CBS Sports.
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