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Nick Bosa is Out and the 49ers’ Injury List Will Make You Look Twice

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The San Francisco 49ers hit their Wednesday practice, and big-name defensive end Nick Bosa is nowhere to be found, nursing a calf injury. Head coach Kyle Shanahan said Bosa “can’t go today, but hopefully we’ll get him in tomorrow,” which is a hopeful spin on a seriously long list of players who were also sitting out.

Bosa’s Absence Headlines a Swarm of Injuries

Bosa’s calf issue is a massive blow, but he’s not alone in the trainer’s room. The 49ers had a whole squad of guys not practicing Wednesday, which was already a walkthrough since they played Monday. That list includes wide receivers Mike Evans (Achilles) and Deebo Samuel (hamstring), adding serious question marks to their passing game. You also have cornerback Upton Stout (shoulder), linebacker Luke Gifford (groin, listed twice so you know it’s bad!), defensive lineman Mykel Williams (knee), linebacker Garret Wallow (hamstring), defensive back Siran Neal (neck), and safety Marques Sigle (ankle) all sidelined. That’s a lot of key guys, and it screams trouble for any team, even one with the Niners’ roster depth.

Who’s Moving Around and What It Means

In some roster shuffling, the 49ers brought defensive tackle Naquan Jones back to the practice squad, releasing linebacker Eugene Asante. On the positive side, linebacker Dre Greenlaw is back at practice, which is a needed boost for their defense. Wide receiver Christian Kirk is also back, with Shanahan noting, “He had a good week of practice last week. He’ll be out there again today. Hopefully, he feels good at the end of the week.” If Kirk can make it through the week, it sounds like he could be activated. As for Evans, don’t hold your breath for him to practice; Shanahan expects him to be a game-time decision.

The number of guys hobbling for the Niners this week is wild. We’ll see if Kirk can actually get activated, and if Evans even suits up. It’s a huge test for their depth and coaching staff.

This article was created with AI assistance and published under Seattle On Tap’s editorial standards. See our Editorial Policy.

Originally reported by Niners Nation.

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