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Christian McCaffrey is OUT, Deebo Samuel is OUT, and the 49ers’ Offense Took a Major Hit

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San Francisco 49ers logo on gradient background — Created by the Sports On Tap desk | Source : Sports On Tap (team logos property of their respective owners)

The San Francisco 49ers are definitely feeling the injury bug heading into their next game, with star running back Christian McCaffrey, wide receiver Deebo Samuel, Mike Evans, and safety Siran Neal all missing Wednesday’s practice. This is a rough start to the week for a team trying to stay on track.

Key Playmakers Sidelined for Now

Head Coach Kyle Shanahan didn’t mince words about the state of his top offensive weapons. McCaffrey is dealing with a hamstring injury that, while “not as bad as Deebo’s,” still kept him off the field. Shanahan noted CMC had a “good week” and might get a chance to be limited in practice tomorrow, but for today, he’s out. That’s a huge blow to their run game.

Then there’s Deebo Samuel, also nursing a hamstring issue. Shanahan stated Deebo is “making progress” but flat out said he “can’t go today” and would be “surprised if he could go this week.” That’s not the news anyone wants to hear about such a dynamic playmaker. Mike Evans, battling Achilles soreness, is also a no-go. Shanahan confirmed they’ve “made a lot of progress” with Evans, saying “Things go in the right direction.” Still, they’ve “got to be smart with” it and aren’t going to “overly do it.” He’s “still working his way to get there,” so no immediate return there either. Siran Neal is also out with a knee/foot injury. It’s a tough look for their availability this week.

Bosa is Back, Plus Other Practice Window Openers

It’s not all doom and gloom though, as some familiar faces are making their way back to the practice field. Defensive end Nick Bosa, dealing with a calf issue, has “made enough progress” to participate in practice, albeit in a limited capacity. That’s a good sign for their pass rush! He’s joined by LB Garret Wallow (hamstring), S Marques Sigle (ankle), LB Luke Gifford (groin), CB Upton Stout (shoulder), WR Demarcus Robinson (ankle), and CB Nate Hobbs (abductor) in the limited practice group.

Even better, the 49ers have officially opened the practice window for Demarcus Robinson and Nate Hobbs. Robinson has been sidelined since Week 2, and Hobbs has been out since mid-August. Shanahan confirmed Robinson is “close to returning” and participated in a walk-through earlier in the week, so he’ll get to go full speed today. The coach noted that Robinson, Bosa, Hobbs, and Sigle “will be out there for the first time today.” Unfortunately, CJ West won’t practice this week, with Shanahan planning to “hold him for another week.” And De’Zhaun Stribling is still “over a month away,” but the expectation is he *will* return.

With so many key players either sidelined or just getting back to limited work, the 49ers are definitely battling the injury bug at a crucial point in their season. How these guys progress this week will absolutely dictate their chances in the upcoming games.

This article was created with AI assistance and published under Seattle On Tap’s editorial standards. See our Editorial Policy.

Originally reported by Niners Nation.

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