Week 4 of the 2026 college football season is absolutely kicking off in a huge way with conference rivalries heating up, and we’re looking at a three-leg parlay that’s got some seriously wild picks, including undefeated USC hosting Oregon in what’s going to be a must-watch showdown.
That Oregon Streak vs. USC Is Getting Tested Hard
Alright, so we’ve got USC rolling in at a perfect 4-0 to start 2026. They just lit up Rutgers in a shootout win last week to kick off their Big Ten schedule. But let’s be real, their defense has been giving up points, 30 to Louisiana-Lafayette in Week 2 and 35 to Rutgers, so they’re not exactly ironclad back there. On the flip side, Oregon’s coming in at 2-1. They grabbed a close win over Boise State and then just blew out Portland State, but that stunning loss at Oklahoma State in Week 2 is still fresh. Plus, even with a shutout win against the Pilots, their defense has been a “big problem” against FCS schools. Both these squads have dynamic offenses led by veteran quarterbacks, so you know this former Pac-12 battle is shaping up to be an absolute fireworks display.
Here’s the kicker though: Oregon has won each of the last five matchups against USC. The Trojans haven’t gotten the upper hand in this rivalry since 2016. That’s a long time! But don’t tell the SportsLine Projection Model that. This thing simulates every FBS game 10,000 times, and it’s calling for USC to win outright in 58% of simulations at plus money. If that doesn’t scream “upset the historical trend” for your parlay, I don’t know what does.
Big Ten Undefeateds Clash and Alabama Gets a Scare?
Speaking of big games, this Week 4 parlay also throws Iowa money line against Michigan into the mix. This is huge because one of these undefeated Big Ten teams is walking off the field Saturday at 4-0, and the other is going to be sitting at 3-1 with a seriously uphill climb toward any potential College Football Playoff appearance. The stakes are sky-high right there. Plus, the parlay is looking at South Carolina +12.5 against Alabama. That’s a bold call against one of the perennial powerhouses!
The SportsLine model that’s powering these picks is off to a profitable 22-19 start on all its top-rated college football picks so far this season, and it got an upgrade for 2026 to factor in the transfer portal even better. Anybody following its calls on betting sites could have seen some strong returns already. You can get in on the action with DraftKings and grab $150 in bonus bets when you spend $5+, or use the FanDuel promo code for up to $250 in bonus bets.
This article was created with AI assistance and published under Seattle On Tap’s editorial standards. See our Editorial Policy.
Originally reported by CBS Sports.
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